Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the IND beta-lactamase family

IND-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......
MKKSIRFFIVSI-LLSPFAS---AQVKDFVIEPPIKNNLHIYKTFGVFGGKEYSANSMYLVTKKGVVLFDVPWEKIQYQSLMDTIKKRHNLPVVAVFATHSHDDRAGDLSFFNNKGIKTYATAKTNEFLKKDGKATSTEIIKTGKPYRIGGEEFVVDFLGEGHTADNVVVWFPKYNVLDGGCLVKSNSATDLGYIKEANVEQWPKTINKLKAKYSKATLIIPGHDEWKGGGHVEHTLELLNKK----
IND-2 .....QLLMM.M-F...LIN---...........V.P..YL..S............AV..T............Q.E...T.....Q...H...I.................Y.Q.............L...................K......M.........V..........K..........RT......TG....K...E.MR...T..AQ...V.............Q...D..D.NKKPE  79.01 %
IND-2a .....QLLMM.M-F...LIN---...........V.P..YL..S............AV..T............Q.E...T.....Q...H...I.................Y.Q.............L...................K......M.........V..........K..........RT......TG....K...E.MR...T..AQ...V....E........Q...D..D.NKKPE  78.60 %
IND-3 ...R.Q..M..M-M..SLF.---.............K....................V....Q............V.........Q.......I............................S...............................................................KA.......................S.....S.V.............K.........----  91.21 %
IND-4 .R.NV.I.T.LSLF.IN.FN---..AR.....Q.FGKQ.YL.......D.....T.AL...............Q.T.................I........S........Y.K...P.........L...E.....SKLT.I..K.K......T...............................SA.V....TG........A.MK..Q...PSTAKV.........ND..K......DQQKQ--  72.73 %
IND-5 ...R.Q..M..M-M.A.MFN---..................................V.................A.................I............................S...............................T.................................................I..D.................D.................----  92.89 %
IND-6 ..RR.Q..M..M-M.T.LF.---.............K..Y.................V.....T...........A..............................................P...Q...R........L..P.....F..........................K.......................L......MH...T...E.V......................D..----  88.28 %
IND-7 ............-.......---....................................................V.......................................................................................................................................................................----  99.58 %
IND-8 .....Q.....M-......N---S............S..Y................AA..K.....I........V.................I............................L..................Q.....H..........................................................M....T...............................----  92.89 %
IND-9 .....Q.....L-......N---............SK..Y................AV.................V.....................................K.............L...E...V.SN..N...A.H..........I.....V..........K..........T.................Q.M.T..S...Q...........................----  88.70 %
IND-10 .....Q.....M-......N---.............S..Y................AA..K.....I........V.................I........................K...L..................Q.....H..........................................................M....T...............................----  92.89 %
IND-11 .....QLLMM.M-F...LIN---...........V.P..YL..S............AV..T............Q.E...T.....Q...H...I.................Y.Q.............L...................K......M.........V..........K..........RT......TG....K...E.MR...T..AH...V.............Q...D..D.NKKPE  79.01 %
IND-12 .....QLLMM.M-F...LIN---...........V.P..YL..S............AV..T............Q.E...T.....Q...H...I.................Y.Q.............L...................K......M.........V..........K..........RT......TG....K...E.MR...T..AQ...V.............Q.S.D..D.NKKPE  78.60 %
IND-14 ...R.Q..M..M-M...LF.---.............K....................V....Q............V.........Q.......I............................................................................................KA.......................S.....S.V............I..........----  92.05 %
IND-15 .....QLLMM.M-F...LIN---...........V.P..YL..S............AV..T............Q.E...T.....Q...H...I.................Y.Q.............L...................K......M.........V.....R....K..........RT......TG....K...E.MR...M..AQ...V.............Q...D..D.NKKPE  78.60 %
IND-16 .....Q.....M-......N---.............S..Y................AA..K.....I........V.................I............................L..................Q.....H..........................................................M....T...............................----  93.31 %
IND-17 .R.....L.I.VLF..Q.VN---...R.........P..Y..........R...T.A................Q.T................II.................Y..........V....L...E.....S..T...................................I.........RN......TG....K...L.MA...S..PG..MVV....................ENKK--  81.82 %
IND-18 ..RN.Q...I.M-......TAQTT..R......Q.QP.FY..............T.AV...............Q.T.....L...Q.......I........E........Y.K.............L...........L..............I....................KI.........KA.V....TG....A...Q.MT...Y...Q.....................D..HN.----  80.99 %
IND-19 .....QLLMM.M-F...LIN---...........V.PK.YL..S............AV..T............Q.E...T.....Q...H...I.................Y.Q.............L...................K......M.........V..........K..........RT......TG....K...E.MR...T..AQ...V.............Q...D..D.NKKPE  78.60 %
B1-IND phylogenetic tree

Last updated: January 08, 2024.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database is funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since December 3rd, 2023)