Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the VIM beta-lactamase family

VIM-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260......
MLKVISSLLVYMTASVMAVASPLAHSGEPSGEYPTVNEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEAEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSANVLYGGCAVHELSSTSAGNVADADLAEWPTSVERIQKHYPEAEVVIPGHGLPGGLDLLQHTANVVKAHKNRSVAE
VIM-2.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.60 %
VIM-3.F.LL.K....L...I..I.....F.VDS.......S......................K....................................................................................V..S...........................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 89.85 %
VIM-4............................................................................................................................................................................................................R............................................................. 99.62 %
VIM-5...............................................................................................................................K........................................................................LA..R...................................................T......... 98.12 %
VIM-6.F.LL.K....L...I..I.....F.VDS.......S......................R....................................................................................V..S...........................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 89.85 %
VIM-7.FQ-.R.F..GIS.F....LGSA.Y.AQ.G......DD.........K.G..........KLGDT..S........A...............V................SI.......................T..L..Q....A...V.A...KA......V.......V........G........AVR..F.......A.RE........N.....ATIK...QR.................E.....T....T..V.P... 77.07 %
VIM-8.F.LL.K....L...I..I.....F.VDS.......S.....................................................................................................A.....V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-9.F.LL.K....L...I..I.....F.VDS.......S.....................................................................................................I.....V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-10.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QY..............K..T......T....V. 90.60 %
VIM-11.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..S...........................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-12..............................................................................................................................................................................................................................I....Q.....QF..............K..T......T....V. 96.99 %
VIM-13.........F.....L............SR......S............D.........HT...V.......................T...V................S..............A........................V..................................................L...R...............G......Q...............................T...... 92.86 %
VIM-14..............................S.............................................................................................................................................................................R............................................................. 99.25 %
VIM-15.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S..F....IY...R.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-16.F.LL.K....L...I..I.....F.VDS.......S.................L.........................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-17.F.LL.K....L...M..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.60 %
VIM-18.F.LL.K....L...I..I.....F.VDS.......S......................R...................................................................................----............................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 89.10 %
VIM-19...............................................................................................................................................................................................K............R............................................................. 99.25 %
VIM-20.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....QR....QF..............K..T......T....V. 90.23 %
VIM-23.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY.....................I....Q.....QF..............K..T......T....V. 90.98 %
VIM-24.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...L.................I....Q.....QF..............K..T......T....V. 90.60 %
VIM-25...............................................................................................................................K........................................................................LA..R............................QF..............K..T......T....V. 96.24 %
VIM-26........................................................................................................................................................................................................L................................................................. 99.62 %
VIM-27.........................................................S................................................................................................................................................................................................................ 99.62 %
VIM-28........................................................................................................................................................................................................L...R............................................................. 99.25 %
VIM-29...............................................................................................................................................................................................K....................................R..................................... 99.25 %
VIM-30.F.LL.K....L...I..I.....F.VDS...................................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.98 %
VIM-31.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......I....R.................I....QR....QF..............K..T......T....V. 90.60 %
VIM-32.................................................................................................................................................A........................................................................................................................ 99.62 %
VIM-33..................................................................................................................................................................................................F....................................................................... 99.62 %
VIM-34..............................................................................................................I........................................................................................................................................................... 99.62 %
VIM-35...................................................................................................................................................................................................................T...................................................... 99.62 %
VIM-36.F.LL.K....L...I..I.....F.VDS.......S......................R....................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-37.........................................................S..................................................................................................................................................R............................................................. 99.25 %
VIM-38...........L...................................................................................................................K........................................................................LA..R...................................................T.......V. 97.37 %
VIM-39..................................A.....................................................................................................................................................................L................................................................. 99.25 %
VIM-40..............................................................................................................................................V.............................................................R............................................................. 99.25 %
VIM-41.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.......N.........I....Q.....QF..............K..T......T....V. 90.23 %
VIM-42..............................................................................................................................................................................................................................I........................................... 99.62 %
VIM-43.......................V....................................................................................................................................................................................R............................................................. 99.25 %
VIM-44.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T...N..T....V. 90.23 %
VIM-45.F.LL.K....L...I..I.....F.VDS.....I.S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-46.F.FL.K....L...I..I.....F.VDS......AS...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-47.F..V....F.....L............SR......S............D.........HT...V.......................T...V................S..............A........................V..................................................L...R...............G......Q...............................T...... 92.11 %
VIM-48.F.FL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.60 %
VIM-49.........................................................S.....................................................................K........................................................................LA..R...................................................T......... 97.74 %
VIM-50.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..S...........................................S.......IY...L.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-51.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R..V..............I....Q.....QF..............K..T......T....V. 90.23 %
VIM-52........................................................................................................................................................................................................R................................................................. 99.62 %
VIM-53...........L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T...... 92.48 %
VIM-54...................................................................................................................................................S........................................................R............................................................. 99.25 %
VIM-55...............................................................................................................................................................................................K............R.......................R..................................... 98.87 %
VIM-56.FTLL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R....G............I....Q.....QF..............K..T......T....V. 89.85 %
VIM-57...........................................................................................................................................................................I.............................................................................................. 99.62 %
VIM-58.F.FL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R....G............I....Q.....QF..............K..T......T....V. 90.23 %
VIM-59....................................................................................................................................................................................................................................R..................................... 99.62 %
VIM-60.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...L.................I....QR....QF..............K..T......T....V. 90.23 %
VIM-61.FQ-.R.F..GIS.F....LGSA.Y.AQ.G......DD.........K.G..........KLGDT..S........A...............V................SI.......................T..L..Q....A...V.A...KA......V.......V........G........AVR..F.......A.RE...Y....N.....ATIK...QR.................E.....T....T..V.P... 76.69 %
VIM-62.F.LL.K....L...I..I....VF.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-63.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I..L.Q.....QF..............K..T......T....V. 90.23 %
VIM-64............................................................................................................................................................................................................L............................................................. 99.62 %
VIM-65.F.LL.K....L...I..I.....F.VDS......AS...........................................................................................................V..............................................S.......IY...R..V..............I....Q.....QF..............K..T......T....V. 89.85 %
VIM-66.F.LL.K....L...I..I.....F.VDS.......S....................................................................................................L......V..............................................S.......IY...L.................I....QR....QF..............K..T......T....V. 89.85 %
VIM-67.F.LL.K....L...I..I.....F.VDS......AS...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-68............................................................................................V............................................................................................................................................................................. 99.62 %
VIM-69.FQ-FR.F..GIS.F....LGSA.Y.AQ.G......DD.........K.G..........KLGDT..S........A................................SI..........................L..Q....A...V.....KA......V.......V........G........AVR..F.......A.RE........N.....ATIK...QR.................E.....TD...T..V.P... 77.44 %
VIM-70............................................................................................................................................................................................................G............................................................. 99.62 %
VIM-71.S....R..............S.S...A..................F....S..........N.T.........................................I...............D..............L....................A........................I......S...F.........R.................L....ER...............T...............I..... 91.73 %
VIM-72.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R....T............I....Q.....QF..............K..T......T....V. 90.23 %
VIM-73.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V.....S........................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-74.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................G.......IY...R.................I....Q.....QF..............K..T......T....V. 90.60 %
VIM-75...........................................................R.............................................................................................................................................................................................................. 99.62 %
VIM-76.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................L..............................................S.......IY...L.................I....QR....QF..............K..T......T....V. 90.23 %
VIM-77.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..D...........................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-78...........................................................R................................................................................................................................................R............................................................. 99.25 %
VIM-79..................................................................................................................................................................................................F.........R............................................................. 99.25 %
VIM-80.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V.....-........................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-81.F.LL.K....L...I..I.....F.VDS...H...S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-82.F.LL.K....L...I..I.....F.VDS.......S......................R....................................................................................V..............................................S.......IY...R....T............I....Q.....QF..............K..T......T....V. 89.85 %
VIM-83.................................................................................................................................................K........................................................................................................................ 99.62 %
VIM-84.F.LL.K....L...I..I.....F.VDS.......S......................R....................................................................................V..............................................S.......IY...L.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-85.F.LL.K....L...I..I.....F.VDS.......S......................R........................................................N...........................V..............................................S.......IY...L.................I....Q.....QF..............K..T......T....V. 89.85 %
VIM-86...............................................................................................................................................................................................K.......................................................................... 99.62 %
VIM-87.F.LL.K....L.T.I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-88....................................Y..................................................................................................................................................................................................................................... 99.62 %
VIM-89.F.LL.K....L...I..I.....F.VDS.......S.....G.....................................................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-90.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R......P..........I....Q.....QF..............K..T......T....V. 90.23 %
VIM-91.F.LL.K....L...I..I.....F.VDS.......S..............................S............................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-92.F.LL.K....L...I..I.....F.VDS.......S...........................................................................................................V..............................................S.......IY...R.................I....Q.....QFI.............K..T......T....V. 90.23 %
VIM-93...........................................................................................................................................................D.............................................................................................................. 99.62 %
VIM-94.F.LL.K....L...I..I.....F.VDS.......S........................................G..................................................................V..............................................S.......IY...R.................I....Q.....QF..............K..T......T....V. 90.23 %
VIM-95...............................................................................................................................K..............................................A.........................LA..R...................................................T......... 97.74 %
VIM-96....................................................................................................................N..................................................................................................................................................... 99.62 %
B1-VIM phylogenetic tree

Last updated: April 06, 2026.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since March 29th, 2025)