Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the SPI beta-lactamase family

SPI-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.........
MRFNKSIFLILFLLTMAHSGFSQEPGLKIEKLTKDFYIYTTYVAYSGVKTSANALYMLSKDGVILFDTPWDPDQYQPLLDSIRNRHHQEVIAVYATHSHEDRAGGFGFFNKKGIPTYATAATNAILKADHKPEATHLIEPDKTIHIGGKQFVIKYFGEGHTADNVVVWFPKEKILDGGCLIKSSEAKNLGFVGEANVKEWPKTIRKIQQTFKKINWVIPGHDGWKQQGHLENTLKLLTQ
SPI-2...................A........................................................................................................................................................................................................................... 99.58 %
SPI-3.........L.....................................................................................................N..............................................................................Y................................................ 98.74 %
SPI-4.........L...................................R.................................................................N..............................................................................Y................................................ 98.33 %
SPI-5...............I........................................I.............................Q...V..............................................V.L...........I.........S............................Y.............S.................................. 95.82 %
SPI-6...............IT.....................................................................Q...V..............................................V.L...........I.........S............................Y.............S.................................. 95.82 %
SPI-7...............IT..............................I........I.............................Q...V....................R.........................V.L...........I.........S............................Y.............S.................................. 94.56 %
SPI-8...............I........................................I.............................Q...V....................R.........................V.L...........M.........S............................Y.....I.......S.................................. 94.98 %
SPI-9...S...L......I............................E..........................................Q....G...............................T.............V.LN........E.I.........S...................................H............Y............................ 93.72 %
B1-SPI phylogenetic tree

Last updated: April 06, 2026.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since March 29th, 2025)