Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the BlaB beta-lactamase family

BlaB-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.........
MLKKIKISLILALGLTSLQAFGQENPDVKIEKLKDNLYVYTTYNTFNGTKYAANAVYLVTDKGVVVIDCPWGEDKFKSFTDEIYKKHGKKVIMNIATHSHDDRAGGLEYFGKIGAKTYSTKMTDSILAKENKPRAQYTFDNNKSFKVGKSEFQVYYPGKGHTADNVVVWFPKEKVLVGGCIIKSADSKDLGYIGEAYVNDWTQSVHNIQQKFSGAQYVVAGHDDWKDQRSIQHTLDLINEYQQKQKASN
BlaB-2..............................D.........................................................................................................................................................................................................R................ 99.20 %
BlaB-3.M..M.WA.V......G.N.....T.E.................................S.......S....E...N.......R........................KSL................D...................D..............H.......D...........G......FL................K..PNV.............TA........S.......... 87.55 %
BlaB-4............................................................................................I.......................................................................................................................................T.........S.......... 98.80 %
BlaB-5...RL.GL.V....F.G..V...Q...I..................K..........M..........S...........................................L......................K............NT......................D........V..G...................I.......PDV.............T.........SD......... 89.16 %
BlaB-6.M.RL.GL.V....F.G..V...Q...I..................K..........M..........S...........................................L......................K............NT......................D........V..G......F............I.......PDV.............T.........S.......... 88.76 %
BlaB-7.M.GL.GL.V....F.G..V...Q...I..................K..........M.....I....S...........................................L......................K.............T......................D........V..G......F............I.......PDV.............T.........S.......... 88.76 %
BlaB-8.M.GL.GL.V....F.G..V...Q...I..................K..........M..........S...........................................L......................K.............T......................D........V..G......F............I.......PDV.............T.........S.......... 89.16 %
BlaB-9.M.GL.GL.V....F.G..V...Q...I..................K..........M..........S...........................................L......................K............NT......................D........V..G......F............I.......PDV.............T.........S.......... 88.76 %
BlaB-10.M.GL.GL.V....F.G..V...Q...I..................K..........M..........S...........................................L......................K.............T......................D........V..G......F............I.......PYV.............T.........S.......... 89.16 %
BlaB-11........................................................................................................................................................................................................................................R................ 99.60 %
BlaB-12.M..M.WA.V......G.N.....T.E.................................S.......S....E...N.......R........................KSL.V..............D...................D......................D...........G......FL................K..PNV.............TA........S.......... 87.55 %
BlaB-13.M..M.WA.V......G.N.....T.E.................................S.......S....E...N.......R........................KSL.V..............D...................D......................D...........G...N..FL................K..PNV.............TA........S.......... 87.15 %
BlaB-14.M.N.MRA...VF.FM.FFM.............R......................................................................................................................................................................................................R................ 94.38 %
BlaB-15...R..GL.V....F.G..V...Q...I..................K..........M..........S...........................................L......................K.............T......................D........V..G...................I.......PDV.............T.........SD......... 89.96 %
BlaB-16.M.RL.GL.V....F.G..V........................SYK.V........I...............E.................................G..K........................E.......................................................F.............Y...........I.............K......S.......... 90.76 %
BlaB-17.................................R......................................................................................................................................................................................................R................ 99.20 %
BlaB-18.M.N.MRA...VF.FM.FFM..........D.........................................................................................................................................................................................................R................ 94.38 %
BlaB-19.M..M.WA.V......G.N.....T.E.................................S.......S....E...N.......R........................KSL................D...................D......................D...........G......FL................K..PNV.............TA........S.......... 87.95 %
BlaB-20.M.N.MRA...VF.FM.FFM.............R...............R......................................................................................................................................................................................R................ 93.98 %
BlaB-21..................K...................................................................................................................................................................................................................................... 99.60 %
BlaB-22.M.RL.GL.V....F.G..V...Q...I..................K..........M......M...S...........................................L......................K.............T......................D........V..G...................I.......PDV.............T.........SD......... 88.76 %
BlaB-23.M..M.WA.V......G.N.....T.E.................................S.......S....E...N.......R........................KSL................D...................D...I..................D...........G......FL................K..PNV.............TA........S.......... 87.55 %
BlaB-24.M.RL.GL.V....F.G..V...Q...I..................K..........M..........S...........................................L......................K.............T......................D........V..G...................I.......PDV.............T.........S.......... 89.56 %
BlaB-25.M.RL.GL.V....F.G..V...Q...I..................K..........M..........S...........................................L......................K.............T......................D........V..G...................I.......PDV.............T.........SD......... 89.16 %
BlaB-26.M.RL.GL.V....F.G..V..........................K..........M..........S...........................................L......................K.............T......................D........V..G......F............I.......PDV.............T.........S.......... 89.96 %
BlaB-27.M.GL.GL.V....F.G..V...Q...I..................K..........M..........S...........................................L......................K.............T......................D........V..G......F............I.......PD..............T.........S.......... 89.56 %
BlaB-28.M.RL.GV.V....F.G..V...Q...I......E...........K..........M..........S.....................................F.....L....................................T......................D........V..G......F............I.......PDV.............T.........S.......... 88.76 %
BlaB-29.M.N.MRA...VF.FM.FFM..........D.................................................................................................................................................A.......................................................R................ 93.98 %
BlaB-30.M.N.MRA...VF.FM.FFM....................................................................................................................................................................................................................R................ 94.78 %
BlaB-31......................................................................................................................................................................L.................................................................R................ 99.20 %
BlaB-32.................................R..............................................................................................................................................L.......................................................R................ 98.80 %
BlaB-33............................................................................................I............................................................................................................................................................ 99.60 %
BlaB-34.M.GL.GL.V....F.G..V...Q...I..................K..........M..........S.............................A.............L......................K.............T......................D........V..G...................I.......PDV.............T.........SD......... 88.76 %
BlaB-35.M..M.WA.V......G.N.....T.E.................................S.......S....E...N.......R........................KSL................D...................D...............L......D...........G......FL................K..PNV.............TA........S.......... 87.55 %
BlaB-36.M.GL.GL.V....F.G..V...Q...I..................K..........V..........S...........................................L....................................T......................D........V..G...................I.......PDV.............T.........SD......... 89.56 %
BlaB-37.EMR..YV.......M...I...Q...I..................K..........M..........S...........................................L......................K............NT......................D........V..G......F............I.......PDV.............T.........S.......... 89.56 %
BlaB-38......LT....F.F.............................SYK.V........M...............E.................................G..K........................E.......................................................F.........................I....................S.......... 93.57 %
BlaB-39.M.GL.GL.V....F.G..V...Q...I..................K..........M..........S......................................G....L......................K.............T......................D........V..G......F.......N....I.......PDV.............T.........S.......... 88.35 %
B1-BlaB phylogenetic tree

Last updated: April 06, 2026.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since March 29th, 2025)