Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
Beta-Lactamase DataBase - Structure and Function Home Enzymes Structures Mutants Kinetics BLAST
Beta-Lactamase DataBase

Sequence alignment for the L2 beta-lactamase family

L2-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300....
MLARRRFLQFSGAAVASSLALPLLARAAGKTAASAPTDAALTAATDFAALEKAVRGRFGVTLLDTASGRRI-GHRQDERFPMCSTFKSVLAATVLSQAERQPALLDTRVPVRDADLLSHAPVTRRHAGKDMTVRDLCRATIITSDNTAANLLFGVVGGPPAVTAFLRSIGDAVSRTDRLEPELNSFAKGDPRDTTTPAAMAATLQRVVLGEVLQLASRQQLADWLIDNETGDACLRAGLGKLWRVRDKTGSNGEDARNDIAVLWPVAGGAPWVLTAYLQAGAISYEQRATVLAQVGRIADRLIG
L2-2 ..............................AT.N......I...S........CA..L.............-................M...........M.....R....GE......................................................AS..T...S......................................P..........................R...G...........................................S..............  93.07 %
L2-3 ......V........................T................T....CA..L.............-............................R..................................................................TS......S.....................G................P..........................R...G..........................................................  95.38 %
L2-4 ...........A..................AT.N......I...S........CA..L.............-................M...........M.....R....GE......................................................AS..T...S......................................P..........................R...G...........................................S..............  92.74 %
L2-20 ..............................AS.R...E..I.T.N......M.CA..L............L-................M...........M.....R..........T.................................................AS......S...........E.............M........D...P......S...................R...G...................LS.................N....G..............  90.10 %
L2-28 ...................V.........APTRA...E..I............CA..L..S.........V-................M...........ARP...R............................................................AS..T...S...........E...........I.M...........RP.................E........R...G...........................................M..............  89.77 %
L2-43 ...............................T.N.....T.............CA..L............F-................M...........T..................................................................AS......S...........E..........................P..........................R...G...................L...T.................Q.V.............E  93.07 %
L2-47 ..............A...............AS.R...E..I.T.N......M.CA..L............L-................M...........A.....R.M...............................V..........................AS..T...S......M....E......................D...P......S...................R...G...................LS.............S...N....G..............  88.78 %
L2-49 ..............................AT.N......I...S........CA..L.............-................M...........T.....R....GE......................................................AS..T...S......................................P..........................R...G...........................................S..............  93.07 %
L2-54 ...........A..................AT.N......I...S........CA..L.............-S...............M...........M.....R....GE......................................................AS..T...S......................................P..........................R...G...........................................S..............  92.41 %
L2-79 ............................AA.TTAT.A...IS...........CA..L............V-................M...........A.....R.....E......................................................AS..T...S......M.R..E.............GS.......Q...P..........................R...G...................R............R..Q.....Q.A..............  88.45 %
L2-80 ...................LA.A...TVAPSSGTPAAN..IAG.A........SG..L...V...GN....G................M.V.N...L.DAGRVS......IAGK....Y...A...V...L.......GALTI.........LE.....S.L.....GQ..S.T.N..N..DV.L..........S......S.A.FAV.NG..P.....F.......Q............R...G.......D.T.........H....A..V.....GASVDDD...A...R..AL..AM..  69.41 %
L2-81 ...........A...................T.N.....T.............CA..L............F-................M...........T....G.............................................................AS......S...........E..........................P..........................R...G...................L...T.CRVN.....S......Q.V.............Q  90.76 %
L2-82 ...................LA.A....VSPSSGISAAN..IAG.A........IG..L...V.N.GN....G................M.V.H...L.DAGRVS......IAEK....Y...A...V...L.......G.LT..........LE.....S.L.....GQ..S.T.N..N..DV.L..........S.....TS.A.FAV.NG..P.....FT......Q............R...G.......D.T.........H....A..V.....GASVDDD...A...R..AL..AM..  69.41 %
L2-C-3 ..P........TS..V.......I.....RGVGTSAAAG.IA...........CA..L...V.........-.........L.....T.......D.SR.V.G...R.....E.........A.......L......................D.............AQ..S.T.S...........E..................L...DA.APGA.......................AR...G.............T.....MG......I......AD.RND...S..............  80.53 %
L2-C-5 ..P........TS..V.......I.....RGVGTSAAAG.IA...........CA..L...V.........-.........L.....T.......D.SR.V.G...R.....E.........A.......L......................D.............AQ..S.T.S...........E..................L...DA.APGA.......................AR...G.............T......R......I......AD..ND...S..............  81.19 %
L2-E-9 ...................LA.A....VSPASGIPA---.IAG.A........SG..L...V.N.GN....G................L.V.H...L.DAGRVS......IAGK....Y...A...V...L.......G.LT..........LE.....S.L.....GQ..SIT.N..N..DV.L.V........S.....TS.A.FAV.NG..P.....F.......Q...........TR...G.......D.T.........H....A..V.....GASVDDD...A...R..AL..AM..  68.42 %
L2-E-10 ...................FA.A.VQPVSASSGIPAAN..IAG.A........SG..L...V.N.GN....G................M.V.H...L.DAGRVS......IAGK....Y...A...V...L.......G.LT..........LE.....S.L.....GQ..SIT.N..N..DV.L..........S.....TS.A.FAV.NG..P...R.F.......Q............R...G.......D.T.........H...TA..V.....GASVDDD...A..-........M..  68.75 %
L2-E-13 ...................FA.A..QPVSASSGIPAAN..IAG.A........SG..L...V.N.GN....G................M.V.H...L.DAGRVS......IAGK....Y...A...V...L.......G.LT..........LE.....S.L.....GQ..SIT.N..N..DV.L..........S.....TS.A.FAV.NG..P...R.F.......Q............R...G.......D.T.........H...TA..V.....GASVDDD...A...R..AL..AM..  68.09 %
L2-E-28 ...................LA.A....VSPSSGISAAN..IAG.A........SG..L...V.N.GN....G................M.V.H...L.DAGRVS......IAEK....Y...A...V...L.......G.LT..........LE.....S.L.....GQ..S.T.N..N..DV.L..........S.....TS.A.FAV.NG..P.....FT......Q..........A.R...G.......D.T.........H....A..V.....GASVDDD...A...R..AL..AM..  69.08 %
L2-E-29 ...................LA.A....VSPSSGISAAN..IAG.A........SG..L...V.N.GN....G................M.V.H...L.DAGRVS......IAEK....Y...A...V...L.......G.LT..........LE.....S.L.....GQ..S.T.N..N..DV.L..........S.....TS.A.FAV.NG..P.....FT......Q............R...G.......D.T.........H....A..V.....GASVDDD...A...R..AL..AM..  69.41 %
L2-E-31 ...................LA.A....VSPSSGLSAAN..IAD.A........SG..L...V.N.GN....G................M.V.H...L.DAGRVS......IAEK....Y...A...V...L.......G.LT..........LE.....S.L.....GQ..S.T.N..N..DV.L..........S.....TS.A.FAV.NG..P.....FT......Q............R...G.......D.T.........H....V..V.....GASVDDD...A...R..TL..AM..  69.41 %
A-L2 phylogenetic tree

Last updated: October 13, 2021.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database is funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu