Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the GES beta-lactamase family

GES-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280..........
MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDR---KEPEMGDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
GES-2 ...............................................................................................................................................................---.....N..........................................................................................................................  99.65 %
GES-3 .......................................................T.........................................K.............................................................---................................................................................................................................  99.30 %
GES-4 .......................................................T.........................................K.............................................................---.....S..........................................................................................................................  98.95 %
GES-5 ...............................................................................................................................................................---.....S..........................................................................................................................  99.65 %
GES-6 .................................................................................................K.............................................................---.....S..........................................................................................................................  99.30 %
GES-7 .................................................................................................K.............................................................---................................................................................................................................  99.65 %
GES-8 .......................................................................................................................L.......................................---................................................................................................................................  99.65 %
GES-9 ...............................................................................................................................................................---.............................................................................S..................................................  99.65 %
GES-10 ...........T...........................................T....................................................................C..................................---................................................................................................................................  98.95 %
GES-11 ...............................................................................................................................................................---.............................................................................A..................................................  99.65 %
GES-12 ...............................................................................................................................................................---........................................................................A....A..................................................  99.30 %
GES-13 .................................................................................................K.............................................................---.....N..........................................................................................................................  99.30 %
GES-14 ...............................................................................................................................................................---.....S.......................................................................A..................................................  99.30 %
GES-15 ...............................................................................................................................................................---..S..S..........................................................................................................................  99.30 %
GES-16 .....................................E.........................................................................................................................---.....S..........................................................................................................................  99.30 %
GES-17 .................................................................................................K.............................................................---.............................................................................A..................................................  99.30 %
GES-18 .........................................................................I.....................................................................................---.....S..........................................................................................................................  99.30 %
GES-19 ..........A....................................................................................................................................................---.............................................................................A..................................................  99.30 %
GES-20 ..........A....................................................................................................................................................---.....S..........................................................................................................................  99.30 %
GES-21 ..........................................................................L....................................................................................---.....S..........................................................................................................................  99.30 %
GES-22 ...............................................................................................................................................................---....L........................................................................A..................................................  99.30 %
GES-23 .................................................L.............................................................................................................---................................................................................................................................  99.65 %
GES-24 .......................................................T.......................................................................................................---.....S..........................................................................................................................  99.30 %
GES-25 ................H............R.................................................................................................................................---.....S..........................................................................................................................  98.95 %
GES-26 ..........A....................................................................................................................................................---................................................................................................................................  99.65 %
GES-27 ...............................................................................................................................................................---..Q..S..........................................................................................................................  99.30 %
GES-28 ...............................................................................................................................................................---.....S........N.................................................................................................................  99.30 %
GES-29 ...............................................................................................................................................................---..A..S..........................................................................................................................  99.30 %
GES-30 ................................C..............................................................................................................................---.....S..........................................................................................................................  99.30 %
GES-31 .....................................E...........................................................K.............................................................---................................................................................................................................  99.30 %
GES-32 .......F........S...N...R............E..........Q......IE...................................R....K....A........................................................---....................................P.............................I.....................D................EQ.....................  94.43 %
GES-33 .................................................................................................K.............................................................---.....S..................................................................A.......................................................  98.95 %
GES-34 .................................................................................................K.............................................................---N....S..........................................................................................................................  98.95 %
GES-35 ...............................................................................................................................................................---....L.......................I................................................A..................................................  98.95 %
GES-36 ...............................................................................................................................................................---...K.S..........................................................................................................................  99.30 %
GES-37 ...............................................................................................................................................................---..T..S..........................................................................................................................  99.30 %
GES-38 .................................................................................................K.............................................................---.............................................................................AQ.................................................  98.95 %
GES-39 .................................................................................................G.............................................................---.....S..........................................................................................................................  99.30 %
GES-40 ..........A....................................................................................................................................................---.....S.......................................................................A..................................................  98.95 %
GES-41 .......F........S...N...R............E..........Q......IE...................................R.........A........................................................---.....S..............................P.............................I.....................D................EQ.....................  94.43 %
GES-42 ...............................................................................................................................................................KER.....S..........................................................................................................................  98.62 %
GES-43 ....Y..........................................................................................................................................................---..S..S..........................................................................................................................  98.95 %
GES-44 .......F........S...N...........................Q..............................................................................................................---........................................................................................D................EQ.....................  97.56 %
GES-45 ...............................................................................................................................................................---........................................................................A.......................................................  99.65 %
GES-46 .................................................................................................K.............................................................---N...............................................................................................................................  99.30 %
GES-47 .......................................................T......................................................Y................................................---.....S..........................................................................................................................  98.95 %
GES-48 .................S.....................................T.......................................................................................................---.....S..........................................................................................................................  98.95 %
GES-49 .....V...........................................................................................K.............................................................---.....S..........................................................................................................................  98.95 %
A-GES phylogenetic tree

Last updated: October 13, 2021.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database is funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu