Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
Beta-Lactamase DataBase - Structure and Function Home Enzymes Structures Mutants Kinetics BLAST
Beta-Lactamase DataBase

Sequence alignment for the SHV-like beta-lactamase family

AAK-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290...
--MRYIRLCIISLFATLPLAVHASPQPLQQITLRESQLSGRVGTIEMDLASGRTLTAWRADQRFPIMRTFTVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMPVGELCAAAITISDTSAANLLLATVGGPAGFTAFLRQIGDNVTRLHRW-----ETELHAALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLLRSVLPAGWFIADKTGAGERGARGIVALLGPNHKAERIVVIYLRDTPASMAERNQQIAGIGAALLEHWQQ
OHIO-1 --...F.......L.....R...G....E..K.S......S..M......RPG........E...M.S..K......G..................R..................T..........M..N.......PA......L..............D..-----....NE...........AR..................................R.I...............................N...........................AG..I....R  87.41 %
OKP-C-1 --...V...V...L.S............E..K.S.........M.................E...M.S..K.L..................R.........A.............T.....T....M..N.......G.......L..............D..-----....NE........................A.H......Q...............I.A.V.P........................DG.P.............................I....R  87.41 %
SHV-1 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.67 %
SHV-1b-b --...........L..............E..K.S.........M.....T...........E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-2 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I................S..............N...............................I....R  91.32 %
SHV-3 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................L...............I................S..............N...............................I....R  90.97 %
SHV-4 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................L...............I................SK.............N...............................I....R  90.62 %
SHV-5 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I................SK.............N...............................I....R  90.97 %
SHV-6 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.......A.........................................I...............................N...............................I....R  91.32 %
SHV-7 --...F.......L..............E..K.S......S..M.................E...M.S..K............................................T..........M..N...............L..............D..-----....NE.................................................I................SK.............N...............................I....R  91.61 %
SHV-8 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.......N.........................................I...............................N...............................I....R  91.32 %
SHV-9 --...........L..............E..K.S.........M.......-.........E...M.S..K............................................T..........M..N.......R.......L..............D..ET-----..NE....................NV...........................I................SK.............N...............................I....R  89.58 %
SHV-11 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-12 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I................SK.............N...............................I....R  90.62 %
SHV-13 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I................A..............N...............................I....R  90.97 %
SHV-14 --...F.......L..............E..K.S......S..M.................E...M.S..K............................................T..........M..N...............L..............D..-----....NE.................................................I...............................N...............................I....R  92.31 %
SHV-15 --...........L..............E..KQS.........M.................E...M.S..K......M........K............................T..........M..N...............L..............D..ET---.--.NE.................................................I................SK.............N...............................I....R  89.93 %
SHV-16 --...........L..............E..K.S.........M.................E...M.S..K......................TH....................T..........M..N...............L..............D..ETDRW....NE.................................................I...............................N...............................I....R  90.72 %
SHV-18 --...F.......L..............E..K.S......S..M.................E...M.S..K............................................T..........M..N...............L..............D..-----....NE.................................................I................AK.............N...............................I....R  91.61 %
SHV-19 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.F...............................................I...............................N...............................I....R  91.32 %
SHV-24 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.......G.........................................I...............................N...............................I....R  91.32 %
SHV-25 --...........L.A............E..KQS.........M.................E...M.S..K............................................T..........V..N...............L..............D..-----....NE.................................................I...............................N...............................I....R  92.31 %
SHV-28 --..F........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-30 --...F.......L..............E..K.S......S..M.................E...M.S..K............................................T..........M..N...............L..............D..-----....NE.................................................I................S..............N...............................I....R  91.96 %
SHV-31 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I.................K.............N...............................I....R  90.97 %
SHV-32 --...........L..............E..K.S.........M.................E...M.S..K............................................T.......V..M..N...............L.......D......D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-33 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I....S..........................N...............................I....R  91.32 %
SHV-34 --...F.......L..............E..K.S......S..M.................G...M.S..K............................................T..........M..N...............L..............D..-----....NE.................................................I................S..............N...............................I....R  91.96 %
SHV-36 --...V.......L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-37 --...........L.A............E..KQS.........M.................E...M.S..K............................................T..........V..N...............L..............D..-----....NE.................................................I...............................N......................H........I....R  91.96 %
SHV-43 --...........L..............E..K.S.........M.................E...M.S..K.......................................F....T..........M..N...............LS.............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-44 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................L...............I...............................N...............................I....R  91.32 %
SHV-45 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L.......D......D..ET---.--.NE.................................................I................SK.............N...............................I....R  90.62 %
SHV-46 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.......................N.........................I................SK.............N...............................I....R  90.62 %
SHV-48 --...........L..............E..K.S.........M.................E...M.S..K............................................TI.........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-49 --...........L..............E..K.S.........M.................E...MIS..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-50 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE...............T..................H..............I...............................N...............................I....R  90.97 %
SHV-51 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N............L..L..............D..ET---.--.NE...A.............................................I...............................N...............................I....R  90.97 %
SHV-55 --..F........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I................SK.............N...............................I....R  90.62 %
SHV-56 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I............R..................N...............................I....R  90.97 %
SHV-57 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--RNE.................................................I...............................N...............................I....R  91.32 %
SHV-59 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N.V.............L..............D..ET---.--.NE.................................................I...............................N.............L.................I....R  90.97 %
SHV-60 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE...............T.................................I...............................N...............................I....R  90.97 %
SHV-61 --.....R.....L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-62 --...........L..............E..KQS.........M.................E...M.S..K......................................Y.....T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-63 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L........E.....D..ET---.--.NE........................N........................I...............................N...............................I....R  90.97 %
SHV-64 --...........L..............E..KQS.........M.................E...M.S..K.L..........................................T..........M..N...............L..............D..ET---.--.NE.................................................I................SK.............N...............................I....R  90.28 %
SHV-66 --...........L..............E..KQS.........M.....................M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I................SK.............N...............................I....R  90.97 %
SHV-70 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............V..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-71 --...........L..............E..K.S.........M.................E...M.S..K......................................Y.....T..........M..N.............V.L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-72 --...F.......L..............E..K.S.........M.................E...M.S..K............................................T..........M..N.............V.L..............D..ET---.--.NE.................................................I............R..................N...............................I....R  90.62 %
SHV-74 --...........L.....T........E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-75 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I..............................HN...............................I....R  91.32 %
SHV-76 --...........L.A............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..-----....NE.........................................E.......I...............................N...............................I....R  91.96 %
SHV-77 --...........L..............E..KQS.........M.................E...M.S..K.A..........................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-78 --...........L..............E..K.S.........M.......S.........E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-79 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NEV................................................I...............................N...............................I....R  90.97 %
SHV-80 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N.............T.L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-81 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...........S...L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-82 --...V.......L........T.....E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.62 %
SHV-84 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I............R..................N...............................I....R  91.32 %
SHV-85 --...........L..M...........E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-86 --..F........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I................SR.............N...............................I....R  90.28 %
SHV-89 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........V..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-93 --...........L..............E..KQS.........M.................E...M.S..K.....T......................................T..........M..N...............L.......D......D..ET---.--.NE.................................................I...............................N...............................I....R  90.62 %
SHV-94 --...........L..............E..KQS.........M.................E...M.S..K...........................H................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-95 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE...............................L.................I...............................N...............................I....R  91.32 %
SHV-96 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE..........................................A......I...............................N...............................I....R  90.97 %
SHV-101 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE..........................................G......I...............................N...............................I....R  91.32 %
SHV-102 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I................A..............N...............................I....R  91.32 %
SHV-103 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................NR..............................I....R  91.32 %
SHV-105 --...F.......L..............E..K.S......S..M.................E...M.S..K............................................T..........M..N...............L.......D......D..-----....NE.................................................I................SK.............N...............................I....R  91.26 %
SHV-106 --..F........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I................S..............N...............................I....R  90.97 %
SHV-107 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I.............A.................N...............................I....R  90.97 %
SHV-108 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N........I......L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-109 --.....R.....L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N............M..................I....R  90.62 %
SHV-111 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE..S..............................................I...............................N...............................I....R  91.32 %
SHV-116 --...........L..............E..K.S.........M..............H..E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-119 --..H........L.......Q......E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.62 %
SHV-121 --...........L.A...V........E..KQS.........M.................E...M.S..K............................................T..........V..N...............L..............D..-----....NE.................................................I...............................N...............................I....R  91.96 %
SHV-122b --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............DPPG----G...NE.................................................I...............................N...............................I....R  91.29 %
SHV-128 --...........L..............E..KQS.........M.................E...M.S..K............................................T....R.....M..N...............L..............D..ET---.--.NE.................................................I................SK.............N..........................T...PI....R  89.58 %
SHV-129 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I................SK.............N...................LD..........I....R  89.93 %
SHV-132 --...........L..............E..K.S.........M.................E...MLS..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-133 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE...........................................G.....I...............................N...............................I....R  91.32 %
SHV-134 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L.....E........D..ET---.--.NE.................................................I................SK.............N...............................I....R  90.28 %
SHV-135 --...........L..............K..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE...............T.................................I...............................N...............................I....R  90.97 %
SHV-137 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N..............AL..............D..ET---.--.NE.................................................I..............................HN...............................I....R  90.97 %
SHV-142 --...........L.A............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..-----....NE.................................................I...............................N...............................I....R  92.31 %
SHV-143 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............DL.ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-144 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N.............V.L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-147 --...........L..............E..K.S.........M.................E...M.SA.K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N.............S.................I....R  90.97 %
SHV-149 --...........L..............E..K.S..R...S..M.................E...M.S..K............................................T..........M..N...............L..S...........D..-----....NE.................................................I...............................N...............................I....R  91.96 %
SHV-150 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I.........................V.....N...............................I....R  91.32 %
SHV-151 --...........L..............E..K.S...P..S..M.................E...M.S..K............................................T..........M..N...............L..............D..-----....NE.................................................I...............................N...............................I....R  92.31 %
SHV-155 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I.....  91.67 %
SHV-156 --...........L..............E..KQS.........M.................E...M.S..K.................P..........................T..........M..N...............L.T............D..ET---.--.NE.................................................I...............................N...............................I....R  90.62 %
SHV-157 --...........L..............E..KQS.........M.................E...M.S..K.M..........................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-158 --...........L..............E..KQS.........M...........A.....E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-159 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.........................................G.......I...............................N...............................I....R  90.97 %
SHV-161 --...........L..............E..K.S......S..M.................E...M.S..K............................................T..........M..N...............L..............D..-----....NE.................................................I...............................N...............................I....R  92.66 %
SHV-168 --...F.......L..............E..K.S.........M.................E...M.S..K............................................T..........M..N.............V.L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-171 --..F......F.L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-172 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N..D............................I....R  90.97 %
SHV-173 --...........L..............E..KQS.........M....Q............E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-175 --...........L..............E..K.S.........M.................E...M.S..K......................................Y.....T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-178 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.......................................V.........I...............................N...............................I....R  90.97 %
SHV-179 --...........L..............E..K.S.........M.................E...M.N..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.67 %
SHV-180 --...........L..............E..K.S......H..M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE...............T.................................I...............................N...............................I....R  90.97 %
SHV-182 --...........L..............E..KQS.........M.................E...M.S..K................................T...........T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-185 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N......M........................I....R  91.32 %
SHV-186 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE...............T.................................I...................C...........N...............................I....R  90.97 %
SHV-188 MVK..........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.LK.NE.................................................I...............................N...............................I....R  90.69 %
SHV-190 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N....................................R  91.67 %
SHV-191 --...........L..............E..K.S.........M.....V...........E...M.S..K............................................T..........M..N...............L.......D......D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-193 --...........L..............E..KQS.........M.................EL..M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-194 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE........................N........................I...............................N...............................I....R  91.32 %
SHV-195 --...........L.N............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE..S..............................................I...............................N...............................I....R  90.97 %
SHV-196 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N.........................E.....I....R  91.32 %
SHV-197 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..NG..............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-198 --...F.......L............S.E..K.S.........M.................E...M.S..K............................................T..........M..N.............V.L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.62 %
SHV-199 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE...............................................S.I...............................N...............................I....R  91.32 %
SHV-201 --...........L..............E..K.S.........M..............H..E...M.S..K..........M.................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-202 MVK..........L..............E..K.S.........M.................E...M.S..K.................R..........................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.34 %
SHV-204 --...........L..............E..K.S.........M.................E...M.S..K.............D........................Y.....T..........M..N.............V.L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.62 %
SHV-205 --..F........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE..........................................A......I...............................N...............................I....R  90.97 %
SHV-206 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I.............................L.N...............................I....R  91.32 %
SHV-207 --...........L..............E..K.S.........M.................E...M.S..K...........................H................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-208 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I......D........................N...............................I....R  91.32 %
SHV-209 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N..........D....L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-210 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE...........................................L.....I...............................N...............................I....R  91.32 %
SHV-211 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N............................W..I....R  91.32 %
SHV-212 --...........L..............E..K.S.........M.................E...M.S..K..........M.................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-213 --...........LP.............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-214 --...........L..............E..K.S.........M.................E...M.S..K............................................T.....V....M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-215 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE..............................H..................I...............................N...............................I....R  90.97 %
SHV-216 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N..............EL.......D......D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-217 --...........L...S..........E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-218 --...........L..............E..K.S.........M....P............E...M.S..K............................................T..........M..N.........F.....L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-219 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N.........................R.....I....R  91.32 %
SHV-220 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.........................P...V.............G.....I...............................N...............................I....R  90.62 %
SHV-221 --......S....L..............E..K.S.........M.G...............E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-222 --...F.......L..............E..K.S.........M.................E...M.S..K............................................T..........M..N.............V.L..............D..ET---.--.NE................................................MI...............................N...............................I....R  90.62 %
SHV-223 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L.......S......D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-224 --...........L..............E..KQS.........M.................E...M.S..K......A.....................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-225 --...........L..............E..KQS.........M.................E...M.S..K............................................S..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-226 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N..........................L....I....R  91.32 %
SHV-227 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE................V................................I...............................N...............................I....R  91.32 %
SHV-228 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............I...............I....R  90.97 %
SHV-229 --...........L..............E..KQS.........M.................E...M.S..K..................K.........................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-232 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N........S......L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-233 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........MG.N...............L..............D..ET---.--.NE.................................................I................S..............N...............................I....R  90.97 %
SHV-234 --...........L..............E..K.S.........M.................E...MLS..K............................................T..........M..N...............L.......D......D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-235 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE...A.............................................I...............................N...............................I....R  91.32 %
SHV-236 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE......H..........................................I...............................N...............................I....R  90.97 %
SHV-237 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N.............V.L..............D..ET---.--.NE....E............................................I...............................N...............................I....R  90.97 %
SHV-239 --...........L..............E..K.S.........M.................E...MIS..K............................................T..........M..N...............L.......D......D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-240 --...........L..............E..KQS.........M.................E...MIS..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-241 --...........L..............E..K.S.........M.................E...MIS..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I..................Q............N...............................I....R  90.97 %
SHV-242 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........MR.N...............L.......D......D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-243 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D.RET---.--.NE....................................M............I...............................N...............................I....R  90.97 %
SHV-244 --..F........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I................SK.............N...............................I....R  90.28 %
SHV-245 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I............R...SK.............N...................LD..........I....R  89.58 %
SHV-246 --...........L..............E..KQS...P.....M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I................SK.............N...............................I....R  90.28 %
SHV-247 --...........L..............E..K.S.........M.....T...........E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I................SK.............N...............................I....R  90.62 %
SHV-248 --...........L..............E..KQS.........M.................E...M.S..K........................S...................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-249 --..F........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N..........................L....I....R  90.97 %
SHV-250 --..F........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I..............E................N...............................I....R  90.97 %
SHV-251 --...F.......L..............E..K.S.........M.................E...M.S..K............................................T..........M..N.............V.L..............D..ET---.--.NE.................................................I...............................N...............................IK...R  90.62 %
SHV-252 --...........L.A............E..KQS.........M.................E...MIS..K............................................T..........M..N........I......L..............D..ET---.--.NE.................................................I...............D...............N...............................I....R  89.93 %
SHV-253 --..H........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-254 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE........................................E........I...............................N...............................I....R  91.32 %
SHV-255 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N........I......L..............D..ET---.--.NE.................................................I...............................N...............................I....R  91.32 %
SHV-P1 --K..........L..............E..K.S.........M.................E...M.S..K........................S...................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N...............................I....R  90.97 %
SHV-P2 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.................................................I................S..............N............S------------------------  31.82 %
SHV-P3 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------W....NE.................................................I..............................DN..............-----------------------  33.80 %
SHV-P7 --..F........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................NN...M.................---------------  86.11 %
SHV-P10 --......N....L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I...............................N......................---------------  86.81 %
SHV-P13 --...........L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I................SK...........G.I......................---------------  85.76 %
SHV-P17 ------------.L..............E..K.S.........M.................E...M.S..K............................................T...F......M..N...............L..............D..ET---.--.NE.F...............................................I................S..............N.....................----------------  82.29 %
SHV-P29 --...........L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I.................K.............N....T.................---------------  86.46 %
SHV-P35 ---------....L..............E..KQS.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.......................I.........................I...............................N-------------------------------------  76.39 %
SHV-P44 ------------.L..............E..K.S.........M.................E...M.S..K............................................T...F......M..N...............L..............D..ET---.--.NE................G................................I................SK.............N.....................----------------  81.94 %
SHV-P46 ------------.L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L.........K....D..ET---.--.NE.................................................I................SK.............N.....................----------------  82.29 %
SHV-P47 --...........L..............D..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.................................................I................SK.............N......................---------------  86.46 %
SHV-P54 ------------.L..............E..K.S.........M.................E...M.S..K............................................T..........M..N...............L..............D..ET---.--.NE.F...............................................I................S..............N.....................----------------  82.64 %
A-SHV-like phylogenetic tree

Last updated: September 18, 2025.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since March 29th, 2025)