Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
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Beta-Lactamase DataBase

Sequence alignment for the SDA beta-lactamase family

SDA-A-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350......
MHPSTSRPSRRTLLTATAGAALAAATLVPG-------TAHASSGGRGHGSGSVSDAERRLAGLERASGARLGVYAYDTGSGRTVAYRADELFPMCSVFKTLSSAAVLRDLDRNGE---------FLSRRILYTQDDVEQADGAGPETGKPQNLANAQLTVEELCEVSITASDNCAANLMLRE-LGGPAAVTRFVRSLGDRVTRLDRWEPELNSAEPGRVTDTTSPRAITRTYGRLVLGDA----LNPRDRRLLTSWLLANTTSGDRFRAGLPDDWTLGDKTGAG-RYGTNNDAGVTWPPGRAPIVLTVLTAKT-EQDAARDDGLVADAARVLAETLG-------------------
SDA-C-1 ..H---PRV.TAVAGLV.VLS.VPLAACGQSDSTAPPSSAKPATSASASLPRPKPYTGDFKK...EFD.......I...T..E.THNDRAR.AYH.T..A.QA.V..STYS-----------LDG.DK.VT..RE.LV---AHS.V.---EKHVDTGM.LK...DA.VRY...T....LFDPRAA..KGLDASLEK...DI..M..E....SRWV..EKR..ST...LAEDLRAF...K.----.RAPE.AQ..T..RT...GDAVI...V.EN.VV.....T.SY..AR..IA.V...DS....IAI.SHRG-TK..EP..E.I.E..S.VVDS.SS------------------  35.28 %
SDA-D-1 .RI---..T..L..G.V.PL..VPLVACGQASGSESGQQPGLG.CGTSAH..ADAH.KEFRA..KKFD.HP....I..RD.QEITH....R.AYG.T..A.QAG.I.AQVL.D.REVRRGAEADGMDKVVH.G..AIL---PNS.V.---EKHVADGMSLR...DAVVAY...T....LFDQ-...RRGS..VLKQ...HT.SM..Y.Q..G..V..DPR..ST...FAEDLRAFAVE.GEKAA.A.N..EQ.ND.MSGSR.GDALI...V.K..KVE..S.QV-K...R..IA.VR........VS.MSHGD-T...EPH.E...E.GL.V.DG.K-------------------  35.63 %
SDA-D-2 .RI---..T..L..G.V.PL..VPLVACGQASGSESAGSSPA.AV.TSAH..ADAH.KEFRA..KKFD.T.....I..AD.QEITH....R.AYG.T..A.QAG.I..KFSET.AKSGGGAEADGMDKVVH.G..AIL---PNS.V.---EKHVADGMSLR...DAVVRY...T....LFDQ-....KGLNAVLKQ...HT.SM..Y.Q..G..V..DPR..ST...FAEDLRAFAVE.GEKAA.A.N..EQ.ND.MSG.A.GDALI...V.K..KVA..S.QV-K...R..IA.VR........VS.MSHGD-T...EPH.E...E..S.V.DG.K-------------------  36.53 %
SDA-D-3 .RI---..T..L..G.V.PL..VPLVACGQASGSESAGSSPA.AV.TSAH..ADAH.KEFRA..KKFD.T.....I..AD.QEITH....R.AYG.T..A.QAG.I..KFSET.AKSGAGAEADGMDKVVH.G..AIL---PNS.V.---EKHVADGMSLR...DAVVRY...T....LFDQ-....KGLNAVLKQ...HT.SM..Y.Q..G..V..DPR..ST...FAEDLRAFAVE.GKKAA.A.N..EQ.ND.MSG.A.GDALI...V.K..KVA..S.QV-K...R..IA.VR........VS.MSHGD-TE..EPH.E...E..S.V.DG.K-------------------  36.23 %
SDA-E-1 .RKP..SLT..SV.G.GL.LGG.---.AL.-------STT..AASA.TTPSENPA.V...RA...EHQ..I..F.LNLAT.ASLLH..H............AA........HD.S---------Q.A.V.R..EA..T-KS.HA.V.K---DHIDTGM.IRD..DAT.RY........L...-....T.....C.....P.............G..D.R......Y..A...Q.....N.----..RP..A...D...R...TLTT..T...KG..VA..S.G.DT...R.E.AIA.T.DG..VL..A..H.PSLPT.PG.TP.IIKL.T..S.AVAPA-----------------  52.52 %
SDA-F-1 .DRT.A..N..AV.ATGV......TAAAA.-------P...AP.RG-------ARV.G..RA...THD....AF.....T..........R..IA.M...IAV.........D..---------V.A..VH..A.Y.K-RS.YS.V..L.E.V..-GM..A....ATL.R...T....L..D-....T.....C..V..H............................G......I...L----.AAH..ER..R.M.D.R..DE...K...A..L.A....G.-D.........A.....P.V..A.Q.TRF-TP..EA.NV...E...L...AMTD------------------  62.22 %
SDA-F-2 .DRT.A..N..AV.ATGV......TAAAA.-------P...AP.RG-------ARV.G..RA...THD....AF.....T..........R..IA.M...IAV.........D..---------V.A..VH..A.Y.K-RS.YS.V..L.E.V..-GM..A....ATL.R...T....L.HD-....T.....C..V..H............................G......I...L----.AAH..ER..R.M.D.R..DE...K...A..L.A....G.-D.........A.....P.V..A.Q.TRF-TP..EA.NV...E...L...AMTD------------------  61.90 %
SDA-G-1 .RAGAV...AVSRRALLTA...LPLAGCGTRERTGSPP.SVRAA...SPGAEGRARVAD..A...EH........LE..T.AE..H....R.AF..T..A.AA....HHHP-----------IRH.E..VTW.RA..D---SIS.V.---EDHIATG...GQ..DAA.RH..GT.G..LM.D-....SRL.AYL.G...S.S.M.QY.....HDP.HDPR...T....ASD.RK......----.T.DR.A...D..VR...G.R.I...V.SG.RVA....T.-N..RA..IA.L...RSS.L.VA.MSDRP-GFRTPPSER.I.EDRGAIVAG.VRHPPTHASGAGAPSRHPGP  38.60 %
SDA-L-1 .GTTGA.....AV...A....V.GIP.GGS-------..F.APR.N-------P.VL.Q.RA..QEHS.......R..AT....LH..E.R..........AV.........D..---------..AT.LF..EQE.K-DS.F..V..L.E...A-GM...R..AAA.CQ...A....L...-....E.....C..V...T.................L....T....GA...E......----.A....ER..G........TE...K...A.........G.-A.............H.P.V.MV...THD-RP..VA.NP...KT.AL..SA..-------------------  64.01 %
A-SDA phylogenetic tree

Last updated: May 02, 2025.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

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