Beta-Lactamase DataBase (BLDB): Structure and Function
Beta-Lactamase DataBase
Beta-Lactamase DataBase - Structure and Function Home Enzymes Structures Mutants Kinetics BLAST
Beta-Lactamase DataBase

Sequence alignment for the LEN beta-lactamase family

LEN-1
........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280......
MRYVRLCVISLLATLPLVVYAGPQPLEQIKQSESQLSGRVGMVEMDLANGRTLAAWRADERFPMVSTFKVLLCGAVLARVDAGLEQLDRRIHYRQQDLVDYSPVSEKHLVDGMTIGELCAAAITLSDNSAGNLLLATVGGPAGLTAFLRQIGDNVTRLDRWETALNEALPGDARDTTTPASMAATLRKLLTAQHLSARSQQQLLQWMVDDRVAGPLIRAVLPPGWFIADKTGAGERGARGIVALLGPDGKPERIVVIYLRDTPASMAERNQHIAGIGQR-------
LEN-2 .................A.D............................S..................................V.................................................................................................................................................................................................AALIEHWQR  95.45 %
LEN-5 ...I.............A..............................S............................................................T.......................................................................................................................................................................AALIEHWQR  95.45 %
LEN-7 .................A.D............................S..................................V.........................T.......................................................................................................................................................................AALIEHWQR  95.10 %
LEN-8 ....................................P...........S...........................................................................................................H........................................................................................................................AALIEHWQR  95.80 %
LEN-9 ................................................S....................................................................................................................................................................................................................................AALIEHWQR  96.50 %
LEN-10 .................A.D............................S............................................................T..................................................................................................................................................L....................AALIEHWQR  95.10 %
LEN-11 .................A.D............................S.............................................................................................................................................................................A......................................................AALIEHWQR  95.45 %
LEN-12 .................A..............................S.............................................................................................................................................................................A......................................................AALIEHWQR  95.80 %
LEN-13 .................A.D............................S...............................................................................................................................................................................................................L....................AALIEHWQR  95.45 %
LEN-15 ................................................S...................................................................................................................................................P.........................A........................................................-------  98.92 %
LEN-16 .................A..............................S............................................................T.......................................................................................................................................................................AALIEHWQR  95.80 %
LEN-18 .................A.D............................S............................................................T....V.............................................................................................................................................L....................AALIEHWQR  94.76 %
LEN-19 .................A..............................S............................................................T....V..................................................................................................................................................................AALIEHWQR  95.45 %
LEN-20 .................A.D............................S............................................................T....V....................................................................................................................................................V.............AALIEHWQR  94.76 %
LEN-21 .................A.D............................S..................................V...V......................................................................................................................................A......................................................AALIEHWQR  94.76 %
LEN-22 .................A.D............................S...................................................................................................................................................P.........................A......................................................AALIEHWQR  95.10 %
LEN-23 .................A..............................S............................................................T..................................................................................................................................................L....................AALIEHWQR  95.45 %
LEN-24 .............N...A.D............................S....................................................................................................................................................................................................................................AALIEHWQR  95.45 %
LEN-25 .................A.D............................S................................................................A..............................................................................................................................................L....................AALIEHWQR  95.10 %
LEN-26 .............N...A..............................S..................................V.........................T..............M...............................................M.................................................A...........................A.......M.....TI.....Q..A..AALIEHWQR  91.96 %
LEN-27 .................A.D............................S............................................................T.......................................................................................................................................................................AALIEHWQR  95.45 %
LEN-28 .............N...A.D............................S...................................................................................................................................................P.........................A......................................................AALIEHWQR  94.76 %
LEN-30 .............N...A.D............................S............................................................T....V..................................................................................................................................................................AALIEHWQR  94.76 %
LEN-31 .................A.D............................S..................................V.........................T....V.........................................H........................................................................................................................AALIEHWQR  94.41 %
LEN-32 .................A.D............................S..............V............................................................................................H...................................................................................................L....................AALIEHWQR  94.76 %
LEN-33 .................A.D............................S..................................V.........................T....V..................................................................................................................................................................AALIEHWQR  94.76 %
LEN-34 .................A..............................S..................................I.........................T.......................................................................................................................................................................AALIEHWQR  95.45 %
LEN-35 ...I.............A..............................S............................................................T....V..................................................................................................................................................................AALIEHWHD  95.10 %
LEN-36 .................A.D............................S.H................................V.........................T....V..................................................................................................................................................................AALIEHWQR  94.41 %
LEN-37 .................A.D............................S..................................V..................................................................................................S..............................................................................................AALIEHWQR  95.10 %
LEN-38 .............N...A..............................S..................................V........................................M................T..............................M.................................................A...........................A..........................AALIEHWQR  93.71 %
LEN-39 .................A..............................S..................................V.........................T....V.........M..........T....................................M.................................................A...........................A..........................AALIEHWQR  93.36 %
LEN-40 .............N...A..............................S..................................V........................................M................V................................................................................A..........................NA..........................AALIEHWQR  93.71 %
LEN-41 .................A.D............................S..................................V........................................M.................................................................................................A..........................NA..........................AALIEHWQR  94.06 %
LEN-42 .................A..............................S..................................V........................................M...............................................M.................................................A...........................A..........................AALIEHWQR  94.41 %
LEN-43 .............N...A..............................S..................................V........................................M...............................................M.................................................A...........................A..........................AALIEHWQR  94.06 %
LEN-51 ................................................S...............................................................................................................................................................................................................L....................AALIEHWQR  96.15 %
LEN-55 .................A.D............................S....................................................................................................................................................................................................................................AALIEHWQR  95.80 %
LEN-58 .................A.D............................S..................................V.........................F.......................................................................................................................................................................AALIEHWQR  95.10 %
LEN-94 .......L...I.A...A.F.S........I.....A....Y......S....................................................................................................................................................................................................................................AALIEHWQR  93.36 %
LEN-95 .................A.D............................S..............V............................................................................................H.............S.....................................................................................L....................AALIEHWQR  94.41 %
LEN-96 ................................................S...............L..................V..............................................................................................................................................................V..................................AALIEHWQR  95.45 %
LEN-97 ................................................S......................................................................................................................................................................................A..........................P..................AALIEHWQR  95.80 %
LEN-98 ....................................P...........S..................................................................................................M.................................................................................................................................AALIEHWQR  95.80 %
LEN-99 ....................................P...........S...P.......................................................................................................H........................................................................................................................AALIEHWQR  95.45 %
LEN-100 ....................................P...........S..............I............................................................................................H........................................................................................................................AALIEHWQR  95.45 %
LEN-101 .................A.D............................S......................................................................................................................................................................................................NN.A....................Q.....AALIEHWQR  94.41 %
LEN-102 .................A.D............................S..................................V......................................................................................................................................S...A........................NN.A....................Q.....AALIEHWQR  93.36 %
LEN-103 ...I...I.........A.H.S........L.................S..................................V.........................T....V..................................................................................................................................................................AALIEHWQR  93.36 %
LEN-104 .................A.D............................S......................................................................................KI...........................................................P.........................A......................................................AALIEHWQR  94.41 %
LEN-105 .................A.D............................S..................................V.....................D..................M................V................................................................................A..........................NA..........................AALIEHWQR  93.36 %
LEN-106 .................A.D............................S..................................V.....................................................I..................................M...........................H.....................A...........................A..........................AALIEHWQR  93.71 %
LEN-107 .................A.D............................S..................................V............E...........................................................................M.................................................A.................................L....................AALIEHWQR  94.06 %
LEN-108 .H...............A.D............................S..................................V.............................................................................................P............................................A......................................................AALIEHWQR  94.41 %
LEN-109 .............N...A.D............................S..........................................P.................T....V..................................................................................................................................................................AALIEHWQR  94.41 %
LEN-110 .............N...A.D............................S............................................................T....V..........................T.......................................................................................................................................AALIEHWQR  94.41 %
LEN-111 .................A..............................S............................................................T....V..................................................................I..............P.........................A......................................................AALIEHWQR  94.41 %
LEN-112 .............N...A..............................S..................................V.........................T..............M.................................................................................................A...........................A..........................AALIEHWQR  94.06 %
LEN-113 .................A..............................S..................................V.........................T....V.........M.................................................................................................A......................................................AALIEHWQR  94.41 %
LEN-114 .................A.D......................M.....S............................................................T.......................................................................................................................................................................AALIEHWQR  95.10 %
LEN-115 .................A.D............................S..................................V.......P.................T....V..................................................................................................................................................................AALIEHWQR  94.41 %
LEN-118 .................A.D............................S..................................V.........................T....V..H...............................................................................................................................................................AALIEHWQR  94.41 %
LEN-119 .................A.D............................S..................................V.........................T....V...........................................................N......................................................................................................AALIEHWQR  94.41 %
LEN-120 .............N...A.D............................S..................................V.........................T....V..................................................................................................................................................................AALIEHWQR  94.41 %
LEN-121 .................A.D............................S..................................V.........................T....V................................................................................................................S.................................................AALIEHWQR  94.41 %
LEN-122 .................A.D............................S..................................V.........................T...................................................................................................................................I...................................AALIEHWQR  94.76 %
LEN-123 ....H............A.D............................S..................................V.........................T.......................................................................................................................................................................AALIEHWQR  94.76 %
LEN-124 .................A.D............................S..................................V.........................T.........................................................................................................................V.............................................AALIEHWQR  94.76 %
LEN-125 .................A.D............................S..................................V.........................T...........................................K................................................................................A..........................................AALIEHWQR  94.41 %
LEN-126 .................A.D............................S..................................V.........................T...........................................K...........................................................................................................................AALIEHWQR  94.76 %
LEN-127 .................A.D............................S............................................................T............................D........................V.................................................................................................................AALIEHWQR  94.76 %
LEN-128 .................A.D............................S............................................................T.........................T.............................................................................................................................................AALIEHWQR  95.10 %
LEN-129 .................A.D............................S..................................................G.........T.......................................................................................................................................................................AALIEHWQR  95.10 %
LEN-130 .................A.D...................G........S............................................................T.......................................................................................................................................................................AALIEHWQR  95.10 %
LEN-132 .................A.D............................S............................................................T.............................................................................................M.........................................................................AALIEHWQR  95.10 %
LEN-133 .................A..............................S............................................................T....V.........................................................................................H........................................................................AALIEHWQR  95.10 %
LEN-134 .................A..............................S............................................................T....V....................................................................................................................................................V.............AALIEHWQR  95.10 %
LEN-135 .................A.D............................S............................................................T....V..................................................................................................................................................................AALIEHWQR  95.10 %
LEN-136 .................A.D............................S............................................................T....V..................................................................................S...............................................................................AALIEHWQR  94.76 %
LEN-137 ....................................P...........S....................................................................................................................................................................................................................................AALIEHWQR  96.15 %
LEN-138 ....................................P...........S...............................................................................................................................................................................................................L....................AALIEHWQR  95.80 %
LEN-139 ................................................S............................................................T.......................................................................................................................................................................AALIEHWQH  96.15 %
LEN-140 .L..............................................S....................................................................................................................................................................................................................................AALIEHWQR  96.15 %
LEN-141 ................................................S..................................................................................................M.................................................................................................................................AALIEHWQR  96.15 %
LEN-142 ................................................S.............................................................................................E......................................................................................................................................AALIEHWQR  96.15 %
LEN-143 ................................................S...........................................................................................H........................................................................................................................................AALIEHWQR  96.15 %
LEN-144 ................................................S....................................................................................................................................................C...............................................................................AALIEHWQR  96.15 %
LEN-145 ................................................S.....................................................................................................................................................................L..............................................................AALIEHWQR  96.15 %
LEN-146 ................................................S..................................V.........................T.......................................................................................................................................................................AALIEHWQR  95.80 %
LEN-147 .................A..............................S............................................................T..................C...............................................................................................................................................L....AALIEHWQR  95.10 %
LEN-148 .................A..............................S............................................................T......................................................................................T...........................................................L....................AALIEHWQR  95.10 %
LEN-149 .........C.......A..............................S............................................................T............................................F..........................................................................................................................AALIEHWQR  95.10 %
LEN-150 .........C.......A..............................S............................................................T.......................................................................................................................................................................AALIEHWQR  95.45 %
LEN-151 .................A..............................S............................................................T.............................C.........................................................................................................................................AALIEHWQR  95.45 %
LEN-152 .................A..............................S............................................................T.................................................................................................E.....................................................................AALIEHWQR  95.45 %
LEN-153 .................A..............................S............................................................T..................................................R....................................................................................................................AALIEHWQR  95.45 %
LEN-154 .................A..............................S..........................................P.................T.......................................................................................................................................................................AALIEHWQR  95.45 %
LEN-155 .................A..............................S............................................................T...........................G...........................................................................................................................................AALIEHWQR  95.45 %
LEN-156 .................A..............................S.................................................G..........T.......................................................................................................................................................................AALIEHWQR  95.45 %
LEN-157 .................A..............................S............................................................T.............................................................................................................................P.........................................AALIEHWQR  95.45 %
LEN-159 .................A..............................S............................................................T...................................................................S...................................................................................................AALIEHWQR  95.45 %
LEN-160 .................A..............................S............................................................T..........................................................R............................................................................................................AALIEHWQR  95.45 %
LEN-161 .................A..............................S............................................................T...............................................................S.......................................................................................................AALIEHWQR  95.45 %
LEN-163 .................A..............................S............................V...............................T.......................................................................................................................................................................AALIEHWQR  95.45 %
LEN-164 .................A..............................S....T.......................................................T.......................................................................................................................................................................AALIEHWQR  95.45 %
LEN-165 .................A..............................S............................................................T..........................................................................................................L............................................................AALIEHWQR  95.45 %
LEN-166 .................A..............................S......................................................I.....T.......................................................................................................................................................................AALIEHWQR  95.45 %
LEN-167 ............T....A..............................S............................................................T.......................................................................................................................................................................AALIEHWQR  95.45 %
LEN-168 .................A..............................S...........................................................................................................H.................................................................A......................................................AALIEHWQR  95.45 %
LEN-169 .................A..............................S..................................V.........................T................................................................................................................A......................................................AALIEHWQR  95.10 %
LEN-170 .................A..............................S............................................................T................................................................................................................A......................................................AALIEHWQR  95.45 %
LEN-171 .................A.D............................S...........................................................................................................H...................................................................................................L....................AALIEHWPR  95.10 %
LEN-172 .................A.D............................S...........................................................................................................H...................................................................................................L.................W..AALIEHWQR  94.76 %
LEN-173 .................A.D............................S...........................................................................................................H...................................................................................................L....................AALIEHWQR  95.10 %
LEN-174 .................A.D............................S..............V.....................................Y...............................................................................................................................................................................AALIEHWQR  95.10 %
LEN-175 .................A.D............................S..............V.....................................................................................................................................................................................................................AALIEHWQR  95.45 %
LEN-176 .........Y.......A.D............................S..............V.....................................................................................................................................................................................................................AALIEHWQR  95.10 %
LEN-177 .............N...A.D............................S..............................................................................................................................................................................................................................Y.....AALIEHWQR  95.10 %
LEN-178 .................A.D............................S.........................................................................V.....................................................................................................................................L....................AALIEHWQR  95.10 %
LEN-179 .................A.D......................A.....S...............................................................................................................................................................................................................L....................AALIEHWQR  95.10 %
LEN-180 .................A.D............................S...................................................................................................................................................T...........................................................L....................AALIEHWQR  95.10 %
LEN-181 .................A.D............................S...................................................................................Q...........................................................................................................................L....................AALIEHWQR  95.10 %
LEN-182 .................A.D............................S..................................................G............................................................................................................................................................L....................AALIEHWQR  95.10 %
LEN-183 .................A.D............................S..............R................................................................................................................................................................................................L....................AALIEHWQR  95.10 %
LEN-184 .................A.D............................S............................................C..................................................................................................................................................................L....................AALIEHWQR  95.10 %
LEN-185 .................A.D............................S...................................................................................................................................................................S................................................................AALIEHWQR  95.45 %
LEN-186 .................A.D............................S.........................G..........................................................................................................................................................................................................AALIEHWQR  95.45 %
LEN-188 .................A.D............................S.......................................................................................................................................R............................................................................................AALIEHWQR  95.45 %
LEN-189 .................A.D............................S....................................................................................................................................................................D...............................................................AALIEHWQR  95.45 %
LEN-190 .................A.D............................S...............................................................................G.......................................................................................L............................................................AALIEHWQR  95.10 %
LEN-191 .................A.D............................S.................................................................................................................K.............................................................................................L....................AALIEHWQR  95.10 %
LEN-192 .................A.D............................S..................................V..............................................................................M.............................................................................................L....................AALIEHWQR  94.76 %
LEN-193 .................A.D............................S.................................................................................................................M.............................................................................................L....................AALIEHWQR  95.10 %
LEN-194 .................A.D............................S..................................V........................................................................................M.................................................A.................................L....................AALIEHWQR  94.41 %
LEN-195 .................A.D..........................................................................................................................................................................................................A......................................................AALIEHWQR  95.80 %
LEN-196 .................A.D............................S............................V................................................................................................................................................A......................................................AALIEHWQR  95.10 %
LEN-197 .................A.D.........................E..S..................................V.................................................................................................................................................................................................AALIEHWQR  95.10 %
LEN-198 .................A.D.........................E..S..................................V...........................................................................................................................G.....................................................................AALIEHWQR  94.76 %
LEN-199 .......I.........A.D............................S..................................V.................................................................................................................................................................................................AALIEHWQR  95.10 %
LEN-200 .................A.D............................S..................................V...................................V.............................................................................................................................................................AALIEHWQR  95.10 %
LEN-201 .................A.D............................S..................................V...................................S.............................................................................................................................................................AALIEHWQR  95.10 %
LEN-202 .................A.D............................S..................................V.....Q...........................................................................................................................................................................................AALIEHWQR  95.10 %
LEN-203 .................A.D............................S..................................V...................................................................................V.............................................................................................................AALIEHWQR  95.10 %
LEN-204 .................A.D............................S..................................V...E.............................................................................................................................................................................................AALIEHWQR  95.10 %
LEN-205 .................A.D............................S..................................V............................................................................................................................................................................T....................AALIEHWQR  95.10 %
LEN-206 .................A.D............................S....T.............................V.................................................................................................................................................................................................AALIEHWQR  95.10 %
LEN-207 .................A.D............................S..................................V........................................................................H........................................................................................................................AALIEHWQR  95.10 %
LEN-208 .................A.D............................S............................T.....V.................................................................................................................................................................................................AALIEHWQR  95.10 %
LEN-209 .................A.D............................S..................................V.............................................................................................................................................................................................S...AALIEHWQR  95.10 %
LEN-210 .................A.D....Q.......................S..................................V.................................................................................................................................................................................................AALIEHWQR  95.10 %
LEN-211 .H...............A.D............................S..................................V..........................................................................................................................................A......................................................AALIEHWQR  94.76 %
LEN-P5 -------..........A.D............................S............................................................T.................................................................................................................................................................Q.....AALI-----  94.31 %
LEN-P6 -------.........................................S..............................................................................................................................................................................................................................Q.....AALI-----  95.37 %
A-LEN phylogenetic tree

Last updated: September 10, 2025.

If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.

The development of the BLDB database was funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).

Contact: contact@bldb.eu

Live statistics (since March 29th, 2025)