 |
|
|
|
Ambler class |
Protein name |
Mutations |
PubMed ID |
DOI |
PDB structures |
Hydrolytic profile |
|---|---|---|---|---|---|---|
| A | KPC-2 | C-ter 292VNGQQ296 deleted | 18625772 | 10.1128/AAC.00163-08 | ||
| A | KPC-2 | G175S | 19731932 | 10.1021/BI9007963 | view | |
| A | KPC-2 | W105F | 20662006 | 10.1002/pro.454 | view | |
| A | KPC-2 | W105N | 20662006 | 10.1002/pro.454 | view | |
| A | KPC-2 | W105L | 20662006 | 10.1002/pro.454 | view | |
| A | KPC-2 | W105V | 20662006 | 10.1002/pro.454 | view | |
| A | KPC-2 | T237S | 20421396 | 10.1128/AAC.00197-10 | view | |
| A | KPC-2 | T237A | 20421396 | 10.1128/AAC.00197-10 | view | |
| A | KPC-2 | R220H | 22687511 | 10.1128/AAC.05769-11 | view | |
| A | KPC-2 | R220A | 22687511 | 10.1128/AAC.05769-11 | view | |
| A | KPC-2 | R220M | 22687511 | 10.1128/AAC.05769-11 | view | |
| A | KPC-2 | R220K | 22687511 | 10.1128/AAC.05769-11 | view | |
| A | KPC-2 | E276A | 22687511 | 10.1128/AAC.05769-11 | view | |
| A | KPC-2 | E276D | 22687511 | 10.1128/AAC.05769-11 | view |
Statistics (number of mutants): Overall (167); class A (91); subclass B1 (35); subclass B2 (3); subclass B3 (6); class C (19); class D (13).
Last updated: January 08, 2024.
If you use BLDB please cite: Naas, T.; Oueslati, S.; Bonnin, R. A.; Dabos, M. L.; Zavala, A.; Dortet, L.; Retailleau, P.; Iorga, B. I., Beta-Lactamase DataBase (BLDB) – Structure and Function. J. Enzyme Inhib. Med. Chem. 2017, 32, 917-919.
The development of the BLDB database is funded in part by the JPIAMR transnational project DesInMBL, the Région Ile-de-France (DIM Malinf) and the Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT).
Contact: contact@bldb.eu